MycoLight(TM) Cyclic-di-GMP Red Sensor

The MycoLight(TM) Cyclic-di-GMP Red Sensor is developed to fluorometrically detect cyclic-di-GMP (c-di-GMP). The sensor generates a red fluorescent signal upon selectively binding to c-di-GMP. The second messenger 3',5'-cyclic-di-guanosine monophosphate (c-di-GMP) is ubiquitous in bacteria and regulates a wide range of bacterial functions, including biofilm formation, which can lead to chronic infections and antibiotic resistance. C-di-GMP exists in both monomer and dimer forms. Currently, there is a lack of sensitive probes for detecting c-di-GMP. The MycoLight(TM) Cyclic-di-GMP Red Sensor addresses this unmet need, offering high sensitivity and selectivity towards the c-di-GMP structure with minimal interference from other secondary messengers like cyclic AMP. Its larger Stokes shift provides improved signals and allows for multiplexing with other fluorophores in imaging applications without spectral overlap.