ICG-Osu *UltraPure Grade*

Correction Factor (280 nm): 0.076. Extinction coefficient (cm^-1 M^-1): 230000. Excitation (nm): 789. Emission (nm): 813. Indocyanine green (ICG) is a cyanine dye used in medical diagnostics for determining cardiac output, hepatic function, and liver blood flow, as well as ophthalmic angiography. With a peak spectral absorption near 800 nm, ICG operates in the infrared spectrum, penetrating retinal layers effectively. This property allows ICG angiography to capture deeper circulation patterns compared to fluorescein angiography. ICG tightly binds to plasma proteins, remaining confined to the vascular system. It has a half-life of 150 to 180 seconds and is exclusively removed by the liver, directed to bile juice. Recent research highlights ICG's ability to target atheromas within 20 minutes of injection, facilitating the in vivo detection of lipid-rich, inflamed, coronary-sized plaques in atherosclerotic rabbits. In experiments using ex vivo fluorescence reflectance imaging, rabbits injected with ICG demonstrated higher plaque target-to-background ratios compared to those injected with saline. An amino-reactive ICG derivative plays a crucial role in forming ICG bioconjugates with antibodies and other biological molecules. This ultra-pure grade ICG-Osu has a minimum purity exceeding 97% and moderate water solubility.