6-dR110 [6-Carboxy-4,7-dichlororhodamine 110]

Compared to fluorescein labeling reagents such as FITC and FAM, 6-dR110 [6-carboxy-4,7-dichlororhodamine 110] reagents give more photostable and pH-independent bioconjugates that have the absorption maximum around the preferred 488 nm excitation wavelength. They are photostable alternative reagents superior to FITC and FAM. 5-carboxy-4,7-dichlororhodamine 110 is one of the four critical 4,7-dichloro-rhodamine dyes used as the BigDye terminators for DNA sequencing in combination with d6G, dTMR and dROX. ABI PRISM® BigDye(TM) Terminator Cycle Sequencing is the classic method for DNA sequencing.