Taurodeoxycholic Acid (sodium salt hydrate)

Taurodeoxycholic acid is a taurine-conjugated form of the secondary bile acid deoxycholic acid (Cay-20756, Cay-18231). Taurodeoxycholic acid stimulates chloride ion secretion through calcium-activated chloride ion channels and cystic fibrosis transmembrane conductance regulator (CFTR) in Calu-3 airway epithelial cell monolayers when applied basolaterally. Serum levels of taurodeoxycholic acid increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.Formal Name: 2-[[(3alpha,5beta,12alpha)-3,12-dihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid, monosodium salt, hydrate. CAS Number: 207737-97-1. Synonyms: TDCA. Molecular Formula: C26H44NO6S . Na [XH2O]. Formula Weight: 521.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 20 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): 3 mg/ml. SMILES: O[C@@H]1CC[C@@]2(C)[C@@](CC[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(NCCS(=O)([O-])=O)=O)([H])C1.[Na+].O. InChi Code: InChI=1S/C26H45NO6S.Na.H2O/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3,,/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33),,1H2/q,+1,/p-1/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-,,/m1../s1. InChi Key: OLPIZAYYAVQETM-GGPRKOIFSA-M. Origin: Animal/Bovine bile.