ZQ-16

ZQ-16 is an agonist of G protein-coupled receptor 84 (GPR84). It induces calcium mobilization in HEK293 cells expressing GPR84 and Galpha16 (EC50 = 0. µM). ZQ-16 is selective for GPR84 over free fatty acid receptor 1 (FFAR1/GPR40), FFAR3/GPR41, GPR119, and FFAR4/GPR120 at 100 µM. ZQ-16 also inhibits forskolin-induced cAMP accumulation and induces beta-arrestin-2 recruitment in HEK293 cells expressing GPR84 (EC50s = 0. and 0. µM, respectively). It induces the production of reactive oxygen species (ROS) in LPS-induced THP-1 cells differentiated by phorbol 12-myristate 13-acetate (PMA, Cay-10008014) but not in LPS-induced isolated mouse bone marrow-derived macrophages (BMDMs). InChI: InChI=1S/C10H16N2O2S/c1-2-3-4-5-6-15-10-11-8(13)7-9(14)12-10/h7H,2-6H2,1H3,(H2,11,12,13,14), InChIKey: UYXOAKRMLQKLQX-UHFFFAOYSA-N, SMILES: O=C1C=C(N=C(N1)SCCCCCC)O