ZM 39923 (hydrochloride)

ZM 39923 is an inhibitor of JAK3 (IC50 = 79 nM) that less potently inhibits epidermal growth factor receptor, JAK1, and cyclin-dependent kinase 4 (IC50s = 2.4, 40, and 10 µM, respectively). In the absence of the reducing agent dithiothreitol, ZM 39923 also inhibits human tissue transglutaminase 2 (TGM2) and the transglutaminase Factor XIIIa (IC50s= 10 and 25 nM, respectively). It breaks down in neutral buffer to form ZM 449829, which is also an inhibitor of JAK3, TGM2, and Factor XIIIa.Formal Name: 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-1-propanone, monohydrochloride. CAS Number: 1021868-92-7. Synonyms: JAK3 Inhibitor IV, Janus-Associated Kinase 3 Inhibitor IV. Molecular Formula: C23H25NO . HCl. Formula Weight: 367.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.25 mg/ml, DMSO: 5 mg/ml, Ethanol: 2 mg/ml. lambdamax: 249, 285, 336, 346 nm. SMILES: O=C(CCN(CC1=CC=CC=C1)C(C)C)C2=CC3=CC=CC=C3C=C2.Cl. InChi Code: InChI=1S/C23H25NO.ClH/c1-18(2)24(17-19-8-4-3-5-9-19)15-14-23(25)22-13-12-20-10-6-7-11-21(20)16-22,/h3-13,16,18H,14-15,17H2,1-2H3,1H. InChi Key: NJTUORMLOPXPBY-UHFFFAOYSA-N.