Zingerone

Zingerone is a phenolic ketone originally isolated from ginger that has antioxidant, anti-inflammatory, anticarcinogenic, and antidiarrheal activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) radicals in a cell-free assay with an EC50 value of 41.6 µmol. Zingerone (6 mg/kg per day) prevents myocardial expression of TNF-alpha, IL-1beta, and IL-6 in rats following myocardial infarction induced by isoproterenol (Cay-15592). It decreases 1,2-dimethylhydrazine-induced tumor incidence by 67% and aberrant crypt foci formation by 68.85% in rats when administered at a dose of 20 mg/kg per day. Zingerone (10 mM) decreases E. coli heat-labile enterotoxin-induced fluid accumulation in the ileal loop of mice.Formal Name: 4-(4-hydroxy-3-methoxyphenyl)-2-butanone. CAS Number: 122-48-5. Synonyms: NSC 15335, Vanillylacetone. Molecular Formula: C11H14O3. Formula Weight: 194.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/m. SMILES: COC1=C(O)C=CC(CCC(C)=O)=C1. InChi Code: InChI=1S/C11H14O3/c1-8(12)3-4-9-5-6-10(13)11(7-9)14-2/h5-7,13H,3-4H2,1-2H3. InChi Key: OJYLAHXKWMRDGS-UHFFFAOYSA-N.