ZINC69391

ZINC69391 is an inhibitor of the protein-protein interaction between Rac1 and the Rho guanine nucleotide exchange factor TIAM1. It inhibits the interaction between Rac1 and TIAM1 in a cell-free assay when used at a concentration of 200 µM. ZINC69391 is also active against chloroquine-resistant and -susceptible strains of P. falciparum (IC50 = 17.56 and 12.56, respectively). It inhibits the proliferation of MDA-MB-231, F3II, and MCF-7 breast cancer cells (IC50s = 48, 61, and 31 µM, respectively). ZINC69391 (10 µM) induces cell cycle arrest at the G1 phase in MDA-MB-231 cells. It inhibits EGF-induced actin polymerization in, and the migration and invasion of, MDA-MB-231 and F3II cells when used at a concentration of 50 µM. In vivo, ZINC69391 (25 mg/kg per day) reduces the number of lung nodules in an F3II murine model of lung metastasis when administered at a dose of 25 mg/kg per day.Formal Name: N-(4,6-dimethyl-2-pyrimidinyl)-N'-[2-(trifluoromethyl)phenyl]-guanidine. CAS Number: 303094-67-9. Molecular Formula: C14H14F3N5. Formula Weight: 309.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/ml, Ethanol: Sparingly Soluble: 1-10 mg/ml. SMILES: CC1=NC(NC(NC2=C(C(F)(F)F)C=CC=C2)=N)=NC(C)=C1. InChi Code: InChI=1S/C14H14F3N5/c1-8-7-9(2)20-13(19-8)22-12(18)21-11-6-4-3-5-10(11)14(15,16)17/h3-7H,1-2H3,(H3,18,19,20,21,22). InChi Key: BEZGMANANMSUSQ-UHFFFAOYSA-N.