Zebularine

Zebularine
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10975-1 1 mg -

1 - 10 business days

25.00€
Cay10975-5 5 mg -

1 - 10 business days

94.00€
Cay10975-10 10 mg -

1 - 10 business days

123.00€
 
Zebularine, a cytidine analog, is a DNA methylation inhibitor that acts by forming a covalent... more
Product information "Zebularine"
Zebularine, a cytidine analog, is a DNA methylation inhibitor that acts by forming a covalent complex with DNA methyltransferases (DNMTs). By stabilizing the binding of DNMTs to DNA, zebularine hinders methylation and decreases dissociation, trapping DNMT and preventing its turnover. Zebularine preferentially targets cancer cells in various human carcinoma cell lines demonstrating IC20 values of 20, 10, 20, and 5 µM for reducing proliferation of TK6, Jurkat, KG-1, and HCT116 cells, respectively. Zebularine exhibits low toxicity in mice even after prolonged administration (0.2 mg/mL drinking water for 113 days in a mouse intestinal cancer model).
Keywords: 1H-beta-D-ribofuranosyl-2-pyrimidinone
Supplier: Cayman Chemical
Supplier-Nr: 10975-1

Properties

Application: DNA methylation inhibitor
MW: 228.2 D
Formula: C9H12N2O5
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 3690-106| Search using CAS
KEGG ID : K00558 | Search using KEGG ID

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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