Zaprinast

Zaprinast
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010421-10 10 mg -

6 - 10 business days*

27.00€
Cay10010421-50 50 mg -

6 - 10 business days*

119.00€
Cay10010421-100 100 mg -

6 - 10 business days*

210.00€
Cay10010421-250 250 mg -

6 - 10 business days*

460.00€
 
The cyclic nucleotide second messenger guanosine 3'5'-cyclic monophosphate (cGMP) is an important... more
Product information "Zaprinast"
The cyclic nucleotide second messenger guanosine 3'5'-cyclic monophosphate (cGMP) is an important mediator of signal transduction and hence a wide range of cellular processes. It can be generated by soluble guanylyl cyclase in response to binding of nitric oxide and degraded via members of the phosphodiesterase (PDE) protein family. Zaprinast, the compound from which sildenafil (Viagra(TM)) was developed, is a cGMP-specific phosphodiesterase inhibitor. It moderately inhibits PDE5 and PDE6 with IC50 values of 0.5-0.76 and 0.15 µM, respectively, and weakly inhibits PDE9, PDE10, and PDE11 with IC50 values of 35, 22, and 11-33 µM, respectively. Zaprinast therefore enhances the vasodilatory effects of nitric oxide in a range of vascular tissues by prolonging the cGMP-mediated activation of cGMP-dependent protein kinase. Zaprinast also activates both the rat and human G protein-coupled receptor, GPR35 with EC50 values of 16 nM and 0.84 µM, respectively. Formal Name: 3,6-dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one. CAS Number: 37762-06-4. Synonyms: 2-(o-Propoxyphenyl)-8-azapurin-6-one, M&B 22,948. Molecular Formula: C13H13N5O2. Formula Weight: 271.3. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 10 mg/ml. SMILES: CCCOc1ccccc1c1[nH]c(=O)c2nn[nH]c2n1. InChi Code: InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19). InChi Key: REZGGXNDEMKIQB-UHFFFAOYSA-N.
Keywords: 2-(o-Propoxyphenyl)-8-azapurin-6-one, M&B 22,948, 3,6-dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one
Supplier: Cayman Chemical
Supplier-Nr: 10010421

Properties

Application: PDE inhibitor
MW: 271.3 D
Formula: C13H13N5O2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 37762-06-4| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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