(Z)-Ligustilide

(Z)-Ligustilide is a phthalide that has been found in A. graveolens and T. montana roots and has diverse biological activities. It inhibits autophagy and restores Nurr77 expression and sensitivity to tamoxifen (Cay-13258) in tamoxifen-resistant MCF-7 cells. (Z)-Ligustilide (8-32 mg/kg) increases cerebral expression of Nrf2 and HO-1 and reduces infarct volume and neuronal loss in a rat model of cerebral ischemia and reperfusion injury. It decreases mechanical and thermal hyperalgesia in a rat model of inflammatory pain induced by complete Freund's adjuvant (CFA). (Z)-Ligustilide restores gait coordination, reduces spinal cord inducible nitric oxide synthase (iNOS) expression, and inhibits production of prostaglandin E2 (PGE2, Cay-14010), TNF-alpha, and IL-1beta in a rat model of spinal cord injury.Formal Name: 3Z-butylidene-4,5-dihydro-1(3H)-isobenzofuranone. CAS Number: 81944-09-4. Synonyms: cis-Ligustilide, Ligustilide A. Molecular Formula: C12H14O2. Formula Weight: 190.2. Purity: >95%. Formulation: (Request formulation change), A neat oil. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, Ethanol: Miscible. lambdamax: 285, 322 nm. SMILES: O=C1O/C(C2=C1C=CCC2)=C\CCC. InChi Code: InChI=1S/C12H14O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h5,7-8H,2-4,6H2,1H3/b11-8-. InChi Key: IQVQXVFMNOFTMU-FLIBITNWSA-N. Origin: Plant/Angelica sinensis.