Z-AEVD-FMK

Description: Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.[1] At 10 µM, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its active form, caspase cascade activation, and apoptosis.[2]. Target: Others, ADC Linker. Smiles: [C@H](C(N[C@H](C(N[C@@H](CC(OC)=O)C(CF)=O)=O)C(C)C)=O)(NC([C@@H](NC(OCC1=CC=CC=C1)=O)C)=O)CCC(OC)=O. References: Park, S.J., Wu, C.H., Gordon, J.D., et al. Taxol induces caspase-10-dependent apoptosis. The Journal of Biological Chemisty 279(49), 51057-51067 (2004).