YW1128

Description: YW1128 is an inhibitor of Wnt/beta-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.1 It decreases protein levels of beta-catenin in the presence of the GSK3beta inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. It decreases the hepatic expression of Wnt target genes, improves glucose tolerance, and prevents body weight increases and hepatic lipid accumulation in mice fed a high-fat diet, but not mice fed normal chow, when administered at a dose of 40 mg/kg every other day for 11 weeks. Target: Others. Smiles: CC=1N(N=NC1C(NC2=NC3=C(C=C2)C=CC=C3)=O)C4=C(C)C=CC=C4. References: Obianom, O.N., Ai, Y., Li, Y., et al. Triazole-based inhibitors of the Wnt/beta-catenin signaling pathway improve glucose and lipid metabolism in diet-induced obese mice. J. Med. Chem. 62(2), 727-741 (2019).