YS-49

YS-49 is an inhibitor of platelet aggregation. It inhibits ADP-, collagen-, or epinephrine-induced platelet aggregation in isolated human platelets (IC50s = 730, 92, and 3.4 µM, respectively). YS-49 also inhibits platelet aggregation and production of thromboxane A2 (TXA2) induced by arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) in isolated rat platelets (IC50s = 3.3 and 32.8 µM, respectively). It reduces LPS-induced contractions in isolated endothelium-denuded rat aortic strips in a concentration-dependent manner. YS-49 (50 mg/kg) decreases thrombus weight in a rat model of arterio-venous shunt thrombosis. It increases survival in a mouse model of septicemia induced by LPS when administered at doses of 10 and 20 mg/kg.Formal Name: 1,2,3,4-tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol, monohydrobromide. CAS Number: 132836-42-1. Molecular Formula: C20H19NO2 . HBr. Formula Weight: 386.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:2): 0.33 mg/ml. lambdamax: 225 nm. SMILES: OC1=C(O)C=C(CCNC2CC3=C(C=CC=C4)C4=CC=C3)C2=C1.Br. InChi Code: InChI=1S/C20H19NO2.BrH/c22-19-11-15-8-9-21-18(17(15)12-20(19)23)10-14-6-3-5-13-4-1-2-7-16(13)14,/h1-7,11-12,18,21-23H,8-10H2,1H. InChi Key: JXFRKNGQHAAJKY-UHFFFAOYSA-N.