Yohimbine (hydrochloride)

Yohimbine is a natural alkaloid that has highest affinity for alpha2-adrenergic receptors (pKis = 8.2, 8.7, and 9.6 for human alpha2A, alpha2B, and alpha2C, respectively), with antagonist activity at these receptors. It less potently antagonizes serotonin 5-HT1 receptors (pKis = 7.3, 6.8, and 7.6 for human HT1A, HT1B, and HT1D, respectively) and alpha1-adrenergic receptors (pKis = 6.7, 6.8, and 6.8 for human alpha1A, alpha1B, and alpha1D, respectively). Yohimbine is used in veterinary medicine to reverse the sedative effects of alpha2-agonists.Formal Name: 17alpha-hydroxy-yohimban-16alpha-carboxylic acid, methyl ester, monohydrochloride. CAS Number: 65-19-0. Synonyms: NIH 9689, NSC 19509, Yohimbe. Molecular Formula: C21H26N2O3 . HCl. Formula Weight: 390.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 220, 271, 289 nm. SMILES: [H][C@]12N(CCC3=C2NC4=C3C=CC=C4)C[C@]5([H])CC[C@H](O)[C@H](C(OC)=O)[C@@]5([H])C1.Cl. InChi Code: InChI=1S/C21H26N2O3.ClH/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24,/h2-5,12,15,17-19,22,24H,6-11H2,1H3,1H/t12-,15-,17-,18-,19+,/m0./s1. InChi Key: PIPZGJSEDRMUAW-VJDCAHTMSA-N.