Yatein

Yatein is a lignan that has been found in C. formosana and has diverse biological activities. It inhibits the cytochrome P450 (CYP) isoform CYP3A4 (IC50 = 1 µM). Yatein inhibits herpes simplex virus 1 (HSV-1) replication in a plaque reduction assay (IC50 = 30.6 µM). It induces apoptosis and production of reactive oxygen species (ROS) in, and is cytotoxic to, A549 and CL1-5 non-small cell lung cancer (NSCLC) cells (IC50s = 3.5 and 1.9 µM, respectively). Yatein inhibits aggregation of rabbit platelets induced by platelet-activating factor (PAF), collagen, or arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) in a concentration-dependent manner.Formal Name: (3R,4R)-4-(1,3-benzodioxol-5-ylmethyl)dihydro-3-[(3,4,5-trimethoxyphenyl)methyl]-2(3H)-furanone. CAS Number: 40456-50-6. Synonyms: Deoxypodorhizone, (-)-Yatein. Molecular Formula: C22H24O7. Formula Weight: 400.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: O=C(OC1)[C@H](CC2=CC(OC)=C(OC)C(OC)=C2)[C@H]1CC3=CC=C4C(OCO4)=C3. InChi Code: InChI=1S/C22H24O7/c1-24-19-9-14(10-20(25-2)21(19)26-3)7-16-15(11-27-22(16)23)6-13-4-5-17-18(8-13)29-12-28-17/h4-5,8-10,15-16H,6-7,11-12H2,1-3H3/t15-,16+/m0/s1. InChi Key: GMLDZDDTZKXJLU-JKSUJKDBSA-N. Origin: Plant/Austrocedrus chilensis.