XMU-MP-1

XMU-MP-1 is an inhibitor of the pro-apoptotic, sterile 20-like kinases MST1 and 2 (IC50s = 71.1 and 38.1 nM, respectively). It is selective for MST1 and 2 over a panel of 468 kinases at a concentration of 1 µM. XMU-MP-1 inhibits phosphorylation of MOB1, LATS1 and 2, and YAP in HepG2 cells as well as MST1 and 2 autophosphorylation in RAW 264.7, U2OS, SW480, RPE1, SNU423, and HepG2 cells in a concentration-dependent manner. It also prevents cell death induced by overexpression of MST2. XMU-MP-1 (1 mg/kg) enhances liver regeneration in mice post partial hepatectomy and reduces liver fibrosis in a mouse model of chronic liver injury.Formal Name: 4-[(6,10-dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]-benzenesulfonamide. CAS Number: 2061980-01-4. Molecular Formula: C17H16N6O3S2. Formula Weight: 416.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 2 mg/ml, Ethanol: 500 µg/ml. lambdamax: 299 nm. SMILES: O=C(N1C)C2=C(C=CS2)N(C)C3=C1C=NC(NC4=CC=C(S(N)(=O)=O)C=C4)=N3. InChi Code: InChI=1S/C17H16N6O3S2/c1-22-12-7-8-27-14(12)16(24)23(2)13-9-19-17(21-15(13)22)20-10-3-5-11(6-4-10)28(18,25)26/h3-9H,1-2H3,(H2,18,25,26)(H,19,20,21). InChi Key: YRDHKIFCGOZTGD-UHFFFAOYSA-N.