XMD16-5

XMD16-5 is an inhibitor of tyrosine kinase non-receptor 2 (TNK2, IC50 = 0.38 µM), which contains mutations in certain cancer cells. It also decreases viability of Ba/F3 cells expressing the oncogenic TNK2 D163E and R806Q mutant proteins (IC50s = 16 and 77 nM, respectively) without affecting viability of parental cell lines up to a concentration of approximately 1 µM.Formal Name: 5,11-dihydro-2-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one. CAS Number: 1345098-78-3. Molecular Formula: C23H24N6O2. Formula Weight: 416.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMSO: 33 mg/ml, DMSO:PBS (pH 7.2) (1:7): 0.125 mg/ml. lambdamax: 297 nm. SMILES: OC1CCN(C2=CC=C(NC3=NC=C(NC(C(C=CC=C4)=C4N5C)=O)C5=N3)C=C2)CC1. InChi Code: InChI=1S/C23H24N6O2/c1-28-20-5-3-2-4-18(20)22(31)26-19-14-24-23(27-21(19)28)25-15-6-8-16(9-7-15)29-12-10-17(30)11-13-29/h2-9,14,17,30H,10-13H2,1H3,(H,26,31)(H,24,25,27). InChi Key: AGLKBEPKKDHHKY-UHFFFAOYSA-N.