XD14

XD14 is a bromodomain-containing protein (BRD) inhibitor. It binds to BRD2, -3, and -4 (Kds = 170, 380, and 160 nM) and inhibits the growth of HL-60 cells (GI50 = ~20 µM). XD14 (10 µM) also inhibits the growth of SR, K562, and MOLT-4 leukemia cells, as well as T47D breast, UO-31 renal, IGROV-1 ovarian, and KM12 colon cancer cells in vitro.Formal Name: 4-acetyl-N-[5-[(diethylamino)sulfonyl]-2-hydroxyphenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide. CAS Number: 1370888-71-3. Molecular Formula: C20H27N3O5S. Formula Weight: 421.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml. lambdamax: 238, 307 nm. SMILES: O=S(C1=CC(NC(C2=C(CC)C(C(C)=O)=C(C)N2)=O)=C(O)C=C1)(N(CC)CC)=O. InChi Code: InChI=1S/C20H27N3O5S/c1-6-15-18(13(5)24)12(4)21-19(15)20(26)22-16-11-14(9-10-17(16)25)29(27,28)23(7-2)8-3/h9-11,21,25H,6-8H2,1-5H3,(H,22,26). InChi Key: DPBKLIVPNYGQQG-UHFFFAOYSA-N.