Xanthotoxol

Xanthotoxol is a coumarin and a major component in C. monnieri that has diverse biological activities. It inhibits proliferation of HeLa and HepG2 cells in vitro (IC50s = 23.59 and 15.57 µM, respectively). Xanthotoxol increases histamine release from mast cells and decreases secretion of TNF-alpha, IL-4, and IL-1beta from RBL-2H3 cells induced by DNP-human serum albumin (DNP-HSA). It is nematocidal against M. incognita (IC50 = 68 mg/L). In vivo, xanthotoxol inhibits predatory mouse and rat killing behavior in dogs and cats when administered at doses ranging from 3 to 100 mg/kg and 5 to 20 mg/kg, respectively. It reduces amphetamine-induced hypermobility in mice and hamsters. Xanthotoxol (5 and 10 mg/kg) reduces brain edema, neutrophil infiltration, blood-brain barrier disruption, production of IL-1beta, TNF-alpha, IL-8, and nitric oxide (NO), and levels of intercellular adhesion molecule-1 (ICAM-1) and E-selectin in a rat model of focal cerebral ischemia.Formal Name: 9-hydroxy-7H-furo[3,2-g][1]benzopyran-7-one. CAS Number: 2009-24-7. Synonyms: 8-Hydroxypsoralen, NSC 401269, Xanthotol. Molecular Formula: C11H6O4. Formula Weight: 202.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 219, 251, 269, 284, 310 nm. SMILES: OC1=C(OC=C2)C2=CC(C=C3)=C1OC3=O. InChi Code: InChI=1S/C11H6O4/c12-8-2-1-6-5-7-3-4-14-10(7)9(13)11(6)15-8/h1-5,13H. InChi Key: JWVYQQGERKEAHW-UHFFFAOYSA-N. Origin: Plant/Angelicae dahuricae radix.