WHI-P180 (hydrochloride)

WHI-P180 is a multi-kinase inhibitor with IC50 values of 4.5 and 66 nM for the human proto-oncogene RET and kinase insert domain receptor (KDR), respectively. It also inhibits EGFR (IC50 = 4 µM) and binds to tau-tubulin kinase 1 (TTBK1, Kds = 0.46 and 0.24 µM for phosphorylated and non-phosphorylated TTBK1, respectively). WHI-P180 inhibits JAK3 and JAK3-driven graft versus host disease responses in mice receiving allogenic bone marrow and splenocyte grafts. WHI-P180 (25 mg/kg, i.p) inhibits IgE-induced vascular hyperpermeability in a mouse model of passive anaphylaxis. InChI: InChI=1S/C16H15N3O3.ClH/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-4-3-5-11(20)6-10,/h3-9,20H,1-2H3,(H,17,18,19),1H InChIKey: MJLLZROGIFJFJJ-UHFFFAOYSA-N SMILES: COC1=CC2=NC=NC(NC3=CC(O)=CC=C3)=C2C=C1OC.Cl