WHI-P154

WHI-P154 is a quinazoline derivative that exhibits immunosuppressive effects by selectively inhibiting JAK3 (IC50 = 1.8 µM versus IC50s > 10 µM for JAK1 and JAK2). It has been reported to inhibit additional kinases including EGFR (IC50 = 4 nM) and VEGFR as well as the non-receptor tyrosine kinases, Abl, Lck, and Src. WHI-P154 is cytotoxic to human glioblastoma cells (IC50 = 813 nM) and has been used to induce the differentiation of neuronal precursor cells.Formal Name: 2-bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol. CAS Number: 211555-04-3. Synonyms: JAK3 Inhibitor II, Janus-Associated Kinase 3 Inhibitor II. Molecular Formula: C16H14BrN3O3. Formula Weight: 376.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 15 mg/ml. lambdamax: 228, 247, 335 nm. SMILES: COC1=C(OC)C=C(C(NC2=CC(Br)=C(O)C=C2)=NC=N3)C3=C1. InChi Code: InChI=1S/C16H14BrN3O3/c1-22-14-6-10-12(7-15(14)23-2)18-8-19-16(10)20-9-3-4-13(21)11(17)5-9/h3-8,21H,1-2H3,(H,18,19,20). InChi Key: CBIAKDAYHRWZCU-UHFFFAOYSA-N.