WAY-181187

A 5-HT6 receptor agonist, increases intracellular cAMP levels in HeLa cells expressing 5-HT6 (EC50 = 6.5 nM), selectively binds to 5-HT6 over 5-HT2B, 5-HT2C, and 5-HT7 (Kis = 2,458, 124, and 679 nM, respectively), selective for 5-HT6 over a panel of 31 receptors and ion channels at 100 nM, increases extracellular GABA levels in the rat frontal cortex at 10 mg/kg, reduces schedule-induced polydipsia, an adjunctive model of compulsive disorder, in rats at 178 mg/kg, has antidepressant-like activity in rats at 17 mg/kg and anxiolytic-like activity in rats at 10 and 17 mg/kg. Formulation: A solid. InChI: InChI=1S/C15H13ClN4O2S2/c16-13-14(19-7-8-23-15(19)18-13)24(21,22)20-9-10(5-6-17)11-3-1-2-4-12(11)20/h1-4,7-9H,5-6,17H2. InChIKey: RYBOXBBYCVOYNO-UHFFFAOYSA-N. SMILES: NCCC1=CN(S(=O)(C2=C(Cl)N=C3N2C=CS3)=O)C4=C1C=CC=C4