W123

Sphingosine-1-phosphate (S1P) modulates skin, vascular endothelial, and immune cells via five distinct G protein-coupled receptors. The S1P type 1 receptor, S1P1, also known as EDG-1, mediates endothelial, lymphoid, and neuronal cell responses to S1P, as well as the synthetic agonist FTY720. W123 is an analog of FTY720 that is a competitive antagonist of S1P1, as measured by GTPgammaS activation, mitogen-activated protein kinase recruitment, cell migration, and ligand-induced receptor internalization. It has a Ki value of 0.69 µM when assessed by SEW2871-induced activation of S1P1. Its specificity for other S1P receptor subtypes remains to be determined.Formal Name: 3-(2-(3-hexylphenylamino)-2-oxoethylamino)propanoic acid. CAS Number: 1345982-24-2. Molecular Formula: C17H26N2O3. Formula Weight: 306.4. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.3 mg/ml. lambdamax: 244 nm. SMILES: OC(CCNCC(NC1=CC(CCCCCC)=CC=C1)=O)=O. InChi Code: InChI=1S/C17H26N2O3/c1-2-3-4-5-7-14-8-6-9-15(12-14)19-16(20)13-18-11-10-17(21)22/h6,8-9,12,18H,2-5,7,10-11,13H2,1H3,(H,19,20)(H,21,22). InChi Key: JXZQHAWCGSVWRW-UHFFFAOYSA-N.