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VUF10460 is a histamine H4 receptor agonist (Kis = 5.01 and 14.13 nM for the human and rat receptors, respectively). It is selective for the rat histamine H4 receptor over the rat histamine H3 receptor (Kis = 34.67 and 1,778.28 nM, respectively). VUF10460 (10 mg/kg) potentiates the formation of HCl-induced ulcers in the rat gastric mucosa, an effect that is not blocked by the histamine H4 receptor antagonist JNJ-7777120 (Cay-10011925).Formal Name: 4-(4-methyl-1-piperazinyl)-6-phenyl-2-pyrimidinamine. CAS Number: 1028327-66-3. Molecular Formula: C15H19N5. Formula Weight: 269.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 100mg/mL. lambdamax: 245, 316 nm. SMILES: CN(CC1)CCN1C2=CC(C3=CC=CC=C3)=NC(N)=N2. InChi Code: InChI=1S/C15H19N5/c1-19-7-9-20(10-8-19)14-11-13(17-15(16)18-14)12-5-3-2-4-6-12/h2-6,11H,7-10H2,1H3,(H2,16,17,18). InChi Key: NIJGWJIOMPHDBP-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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