VRK-IN-1

VRK-IN-1 is an inhibitor of vaccinia-related kinase 1 (VRK1. IC50 = 150 nM). It is selective for VRK1 over a panel of 48 additional kinases at 1 µM. Formal Name: 4,4'-(2-methylpyridine-3,5-diyl)bis(2,6-difluorophenol). CAS Number: 2378855-09-3. Synonyms: Vaccinia-related Kinase 1-IN-1 Vaccinia-related Kinase-1 Inhibitor 1 VRK Inhibitor 1. Molecular Formula: C18H11F4NO2. Formula Weight: 349.3. Purity: >98%. Formulation (Request formulation change): A solid. Solubility: Water: Slightly soluble: 0.1-1 mg/ml. SMILES: FC1=CC(C2=CN=C(C)C(C3=CC(F)=C(O)C(F)=C3)=C2)=CC(F)=C1O. InChi Code: InChI=1S/C18H11F4NO2/c1-8-12(10-5-15(21)18(25)16(22)6-10)2-11(7-23-8)9-3-13(19)17(24)14(20)4-9/h2-7,24-25H,1H3. InChi Key: PMRGRXLXKYUDIH-UHFFFAOYSA-N. Storage: -20°C. Stability: > 4 years.