VLX600

Description: VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent. It acts by reducing mitochondrial oxidative phosphorylation in tumor cells. Target: Autophagy, Mitochondrial Metabolism, OXPHOS. Smiles: CC(=NNc1nnc2c(n1)[nH]c1c(C)cccc21)c1ccccn1. References: Xiaonan Zhang , Mårten Fryknäs , Emma Hernlund,et al. Induction of Mitochondrial Dysfunction as a Strategy for Targeting Tumour Cells in Metabolically Compromised Microenvironments[J].Nat Commun. 2014,5:3295.