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Vinyl-L-NIO is a potent, selective inhibitor of nNOS. The Ki values for inhibition of nNOS, eNOS, and iNOS by vinyl-L-NIO are 100 nM, 12 and 60 µM, respectively, as determined using initial rate measurements. In the presence of NADPH and O2, vinyl-L-NIO irreversibly inactivates nNOS with a kinact of 0.078 min-1 and a Ki value of 90 nM. Vinyl-L-NIO does not inactivate iNOS. eNOS requires 20-fold higher concentrations of vinyl-L-NIO to obtain 75% the rate of inactivation seen with nNOS.Formal Name: N5-(1-imino-3-butenyl)-L-ornithine, monohydrochloride. CAS Number: 728944-69-2. Molecular Formula: C9H17N3O2 . HCl. Formula Weight: 235.7. Purity: >95%. Formulation: (Request formulation change), A film. Solubility: DMF: 60 mg/ml, DMSO: 50 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: C=CCC(NCCC[C@H](N)C(O)=O)=N.Cl. InChi Code: InChI=1S/C9H17N3O2.ClH/c1-2-4-8(11)12-6-3-5-7(10)9(13)14,/h2,7H,1,3-6,10H2,(H2,11,12)(H,13,14),1H. InChi Key: DIWIMDZKSYTKCZ-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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