VH 032 Linker 6

VH 032 linker 6 is a precursor in the synthesis of proteolysis-targeting chimeras (PROTACs) that contains a terminal alkyne conjugated via a PEG linker to VHL ligand 1 (Cay-21591), which binds to VHL E3 ligase. It has been used in the synthesis of PROTACs targeting Bcl-xL in senescent cells.Formal Name: (4R)-3-methyl-N-[2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]acetyl]-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide. CAS Number: 2098799-80-3. Molecular Formula: C31H42N4O7S. Formula Weight: 614.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 10 mg/ml, Ethanol: 30 mg/ml. SMILES: O=C([C@@H](NC(COCCOCCOCC#C)=O)C(C)(C)C)N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O. InChi Code: InChI=1S/C31H42N4O7S/c1-6-11-40-12-13-41-14-15-42-19-26(37)34-28(31(3,4)5)30(39)35-18-24(36)16-25(35)29(38)32-17-22-7-9-23(10-8-22)27-21(2)33-20-43-27/h1,7-10,20,24-25,28,36H,11-19H2,2-5H3,(H,32,38)(H,34,37)/t24-,25+,28-/m1/s1. InChi Key: HHXQNDSXTCIWSG-CERRFVOPSA-N.