VH 032 Linker 2

VH 032 Linker 2 is a derivative of the proteolysis-targeting chimera technology (PROTAC) building block VHL ligand 1 (Cay-21591). VH 032 Linker 2 comprises the von Hippel-Lindau (VHL) ligand domain and the polyethylene glycol (PEG) linker of the bromodomain and extra terminal (BET) inhibitor-containing PROTACs MZ2 and MZP-55.Formal Name: (2S,4R)-1-((S)-17-amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, monohydrochloride. CAS Number: 2064292-52-8. Synonyms: E3 Ligase Ligand-Linker Conjugate 7. Molecular Formula: C32H49N5O8S . HCl. Formula Weight: 700.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1.1 mg/ml, DMSO: 1.1 mg/ml, Ethanol: 0.7 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 271 nm. SMILES: O=C([C@@H](NC(COCCOCCOCCOCCN)=O)C(C)(C)C)N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O.Cl. InChi Code: InChI=1S/C32H49N5O8S.ClH/c1-22-28(46-21-35-22)24-7-5-23(6-8-24)18-34-30(40)26-17-25(38)19-37(26)31(41)29(32(2,3)4)36-27(39)20-45-16-15-44-14-13-43-12-11-42-10-9-33,/h5-8,21,25-26,29,38H,9-20,33H2,1-4H3,(H,34,40)(H,36,39),1H/t25-,26+,29-,/m1./s1. InChi Key: MSKHBFIXTCSMKP-DDLJGEAHSA-N.