Vapendavir-d5

Vapendavir-d5 is intended for use as an internal standard for the quantification of vapendavir (Cay-30546) by GC- or LC-MS. Vapendavir is a capsid-binding antiviral agent. It binds to a pocket in the human rhinovirus (HRV) strain HRV2 VP1 capsid protein and inhibits the cytopathic effects of HRV2 and HRV14 in HeLa Ohio cells (EC50s = 1 and 5 ng/ml, respectively), as well as in a panel of 39 HRV clinical isolates (median EC50 = 7.3 ng/ml). Vapendavir inhibits replication in a panel of 21 enterovirus 71 (EV71) isolates with an average EC50 value of 0.7 µM.Formal Name: 3-(ethoxy-d5)-6-[2-[1-(6-methyl-3-pyridazinyl)-4-piperidinyl]ethoxy]-1,2-benzisoxazole. CAS Number: 2738376-73-1. Synonyms: BTA798-d5. Molecular Formula: C21H21D5N4O3. Formula Weight: 387.5. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: CC1=CC=C(N=N1)N(CC2)CCC2CCOC3=CC=C(C(OC([2H])([2H])C([2H])([2H])[2H])=NO4)C4=C3. InChi Code: InChI=1S/C21H26N4O3/c1-3-26-21-18-6-5-17(14-19(18)28-24-21)27-13-10-16-8-11-25(12-9-16)20-7-4-15(2)22-23-20/h4-7,14,16H,3,8-13H2,1-2H3/i1D3,3D2. InChi Key: DKSVBVKHUICELN-WNWXXORZSA-N.