Urolithin A

Urolithin A is a secondary metabolite of ellagic acid (Cay-10569), a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties. It decreases proliferation in ECC-1, Ishikawa, and HEC-1A human endometrial cancer cell lines at a concentration of 1 µM, arrests the cell cycle at the G2/M transition, and modulates estrogen receptor-regulated gene expression. It also potentiates the antiproliferative effect of 5-fluorouracil (Cay-14416) in Caco-2, SW480, and HT-29 cells. In a rat model of colitis, urolithin A reduces inflammation, decreasing prostaglandin E2 (PGE2, Cay-14010) levels and preventing upregulation of COX-2 gene expression and protein levels in colonic mucosa. It also induces mitophagy in C. elegans, C2C12 myoblasts, and Mode-K intestinal cells in correlation with improved fitness and extended lifespan in C. elegans and increased exercise capacity in mice.Formal Name: 3,8-dihydroxy-6H-dibenzo[b,d]pyran-6-one. CAS Number: 1143-70-0. Synonyms: 2',7-Dihydroxy-3,4-benzocoumarin, 3,8-Dihydroxy Urolithin. Molecular Formula: C13H8O4. Formula Weight: 228.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml, Ethanol: slightly soluble. lambdamax: 221, 233, 282, 308, 357 nm. SMILES: OC(C=C1)=CC2=C1C3=CC=C(O)C=C3C(O2)=O. InChi Code: InChI=1S/C13H8O4/c14-7-1-3-9-10-4-2-8(15)6-12(10)17-13(16)11(9)5-7/h1-6,14-15H. InChi Key: RIUPLDUFZCXCHM-UHFFFAOYSA-N.