uPSEM 792 hydrochloride

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
TGM-T36810-5mg	5 mg				5 - 10 business days*		279.00€
TGM-T36810-25mg	25 mg				5 - 10 business days*		1,097.00€

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Description: Ultrapotent PSEM (uPSEM) agonist for PSAM4-GlyR and PSAM4-5HT3 (Ki = 0.7 nM for... more

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Product information "uPSEM 792 hydrochloride"

Description: Ultrapotent PSEM (uPSEM) agonist for PSAM4-GlyR and PSAM4-5HT3 (Ki = 0.7 nM for PSAM4-GlyR and <10 nM for PSAM4-5HT3). Exhibits >10,000-fold agonist selectivity for PSAM4-GlyR over alpha7-GlyR, alpha7-5HT3, and 5HT3-R, and 230-fold selectivity over alpha4beta2 nAChR. Also weak partial agonist (~10 %) at alpha4beta2 nAChR. Retains the potency of varenicline for PSAM4-GlyR with enhanced chemogenetic selectivity. Does not act as a substrate for P-glycoprotein pumps. Silences neurons in vivo. Brain-penetrant. Target: Others. References: Magnus et al (2019) Ultrapotent chemogenetics for research and potential clinical applications. Science doi: 10.1126/science PMID:30872534

Supplier:	TargetMol
Supplier-Nr:	T36810

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Storage:	-20°C
Shipping:	+20°C (International: +4°C)

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Our products are for laboratory research use only: Not for administration to humans!

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