UoS 12258

Description: Positive allosteric modulator of AMPA receptors (pEC50 = 5.2 for potentiation of AMPA-mediated currents in vitro). Also potentiates AMPA-mediated synaptic responses in vivo. Improves performance of rats in various learning and memory paradigms. Target: Others. Smiles: N(S(C(C)C)(=O)=O)[C@@H]1CC=2C(C1)=CC=C(C2)C=3C=CC(F)=NC3. References: Ward et al (2010) Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator. J.Med.Chem. 53 5801 PMID:20614889