UoS 12258

UoS 12258 is a positive allosteric modulator of AMPA receptors. It potentiates glutamate-induced currents in HEK293 cells expressing human ionotropic glutamate receptor 2 (GluR2) homomeric AMPA receptors (EC50 = 2.51 µM), as well as HEK293 cells expressing GluR1, GluR3, or GluR4 homomeric AMPA receptors. UoS 12258 (0.3 and 1 mg/kg) increases novel object exploration in a novel object recognition test in rats. It also reduces escape latencies in the Morris water maze in aged rats.Formal Name: N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide. CAS Number: 875927-64-3. Molecular Formula: C17H19FN2O2S. Formula Weight: 334.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 2 mg/ml, Ethanol: 1 mg/ml. lambdamax: 250 nm. SMILES: CC(C)S(N[C@@H]1CC2=CC(C3=CN=C(F)C=C3)=CC=C2C1)(=O)=O. InChi Code: InChI=1S/C17H19FN2O2S/c1-11(2)23(21,22)20-16-8-13-4-3-12(7-15(13)9-16)14-5-6-17(18)19-10-14/h3-7,10-11,16,20H,8-9H2,1-2H3/t16-/m0/s1. InChi Key: QXQSUBKWSHMXDP-INIZCTEOSA-N.