UNBS5162

UNBS5162 is a naphthalimide that antagonizes the expression of CXCL chemokines. In vitro exposure of PC-3 prostate cancer cells to 1 µM UNBS5162 for five successive days was shown to decrease the expression of proangiogenic CXCL chemokines. UNBS5162 also demonstrates antiangiogenic properties in vivo in an orthotopic PC-3 model.Formal Name: N-[2-[2-(dimethylamino)ethyl]-2,3-dihydro-1,3-dioxo-1H-benz[de]isoquinolin-5-yl]-urea. CAS Number: 956590-23-1. Molecular Formula: C17H18N4O3. Formula Weight: 326.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 2 mg/ml. lambdamax: 226, 249, 339, 384 nm. SMILES: O=C(C1=CC(NC(N)=O)=CC2=C1C3=CC=C2)N(CCN(C)C)C3=O. InChi Code: InChI=1S/C17H18N4O3/c1-20(2)6-7-21-15(22)12-5-3-4-10-8-11(19-17(18)24)9-13(14(10)12)16(21)23/h3-5,8-9H,6-7H2,1-2H3,(H3,18,19,24). InChi Key: WCKZRLOUKYFJDY-UHFFFAOYSA-N.