Umifenovir-d6 (hydrochloride)

Umifenovir-d6 is intended for use as an internal standard for the quantification of umifenovir (Cay-16933) by GC- or LC-MS. Umifenovir is a broad-spectrum antiviral agent. It inhibits the replication of H5N1 influenza (IC50 = 30 µg/ml) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro (IC50 = 3.537 µM). Umifenovir inhibits entry of hepatitis C virus (HCV) pseudoparticles in Huh7 cells (IC50 = 6 µg/ml) and inhibits Zika virus protein synthesis in Vero cells. In vivo, umifenovir (45 mg/kg) reduces the formation of influenza-induced lung lesions in ferrets.Formal Name: 6-bromo-4-[((dimethyl-d3)amino)methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-1H-indole-3-carboxylic acid, ethyl ester, monohydrochloride. CAS Number: 2928218-29-3. Molecular Formula: C22H19D6BrN2O3S . HCl. Formula Weight: 519.9. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solid. Solubility: Chloroform: slightly soluble, Methanol: slightly soluble. SMILES: CN1C(CSC2=CC=CC=C2)=C(C(OCC)=O)C3=C(CN(C([2H])([2H])[2H])C([2H])([2H])[2H])C(O)=C(Br)C=C31.Cl. InChi Code: InChI=1S/C22H25BrN2O3S.ClH/c1-5-28-22(27)20-18(13-29-14-9-7-6-8-10-14)25(4)17-11-16(23)21(26)15(19(17)20)12-24(2)3,/h6-11,26H,5,12-13H2,1-4H3,1H/i2D3,3D3,. InChi Key: OMZHXQXQJGCSKN-HVTBMTIBSA-N.