UAMC 0039 (hydrochloride)

UAMC 0039 is a potent inhibitor of dipeptidyl peptidase 2 (DPP-2, IC50 = 0.48 nM). It also inhibits DPP-4 (IC50 = 165 µM). DPP-2 is thought to be involved in degradation of collagen, substance P, and some proline-containing neuropeptides.Formal Name: (2S)-2-amino-4-[[(4-chlorophenyl)methyl]amino]-1-(1-piperidinyl)-1-butanone, dihydrochloride. CAS Number: 697797-51-6. Molecular Formula: C16H24ClN3O . 2HCl. Formula Weight: 382.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/mL, DMSO: 14 mg/mL, Ethanol: 5 mg/mL, PBS (pH 7.2): 10 mg/mL. lambdamax: 220 nm. SMILES: O=C([C@@H](N)CCNCC1=CC=C(Cl)C=C1)N2CCCCC2.Cl.Cl. InChi Code: InChI=1S/C16H24ClN3O.2ClH/c17-14-6-4-13(5-7-14)12-19-9-8-15(18)16(21)20-10-2-1-3-11-20,,/h4-7,15,19H,1-3,8-12,18H2,2*1H/t15-,,/m0../s1. InChi Key: IWXMOQGMIWZNPR-CKUXDGONSA-N.