U-73122

U-73122
Item number Size Datasheet Manual SDS Delivery time Quantity Price
AG-CR1-3698-M001 1 mg -

3 - 9 business days*

22.00€
AG-CR1-3698-M005 5 mg -

3 - 9 business days*

77.00€
 
White to off-white solid. Soluble in methylene chloride or chloroform (10mg/ml). Slightly soluble... more
Product information "U-73122"
White to off-white solid. Soluble in methylene chloride or chloroform (10mg/ml). Slightly soluble in DMSO (2mg/ml), DMF (2mg/ml) or 100% ethanol (1mg/ml). Sparingly soluble in aqueous solutions. See also Solubility Note below. Chemical. CAS: 112648-68-7. Formula: C29H40N2O3. MW: 464.6. Gasdermin D N-terminal fragment (GSDMD-N)-induced pyroptosis inhibitor. Protects against GSDMD-N cytotoxicity in macrophages or against lethal infection in mice. Useful agent for inflammasome research. Potent cell permeable phospholipase C (PLC) , phospholipase A2 and 5-LO (5-lipoxygenase) inhibitor. Affects the phospholipases by inhibiting the hydrolysis of PPI (phosphatidylinositol) to IP3 (inositol triphosphate), which in turn leads to a drop in cytosolic Ca2+. Potent inhibitor of the SERCA pump in smooth muscle. Potently inhibits Ca2+-release from isolated smooth muscle cells independent of its effect on PLC. Inhibits agonist-induced platelet aggregation. Potently inhibits human polymorphonuclear neutrophil adhesion on biological surfaces and exhibits antinociceptive activity in vivo. Shown to inhibit agonist-induced down-regulation of muscarinic receptors in SK-N-SH neuroblastoma cells. Activates TRPM4 and inhibits TRPM3 channels. Potent human telomerase inhibitor.
Keywords: 1-[6-[[(17beta)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-CR1-3698

Properties

MW: 464,6 D
Formula: C29H40N2O3
Purity: >95%
Format: Solid

Database Information

CAS : 112648-68-7| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P280, P302+P352, P304+P340, P305+P351+P338, P405
Caution
Our products are for laboratory research use only: Not for administration to humans!
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