U-18666A

U-18666A
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10009085-5 5 mg -

6 - 10 business days*

48.00€
Cay10009085-10 10 mg -

6 - 10 business days*

90.00€
Cay10009085-25 25 mg -

6 - 10 business days*

214.00€
Cay10009085-50 50 mg -

6 - 10 business days*

380.00€
 
Impaired trafficking of cholesterol to or from the endoplasmic reticulum (ER) has been implicated... more
Product information "U-18666A"
Impaired trafficking of cholesterol to or from the endoplasmic reticulum (ER) has been implicated in many disease states including Neimann-Pick disease type C (NPC), Alzheimers disease and atherosclerosis. U-18666A is a cell permeable drug that inhibits cholesterol trafficking. It inhibits cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum (ER), but not cholesterol transport to the plasma membrane as demonstrated in many cell types including macrophages, primary cortical neurons and primary fibroblasts. In macrophages, micromolar concentrations of U-18666A inhibit multiple pathways of cholesterol trafficking from late endosomes, whereas nanomolar concentrations impair cholesterol trafficking to the ER, a response similar to that found in NPC. U-18666A inhibits oxidosqualene cyclase at high (>0.5 mM) concentrations and oral doses (10 mg/kg) induces cataracts in rats. Formal Name: 3beta-[2-(diethylamino)ethoxy]-androst-5-en-17-one, monohydrochloride. CAS Number: 3039-71-2. Molecular Formula: C25H41NO2 . HCl. Formula Weight: 424.1. Purity: >95%. Formulation: A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 0.5 mg/ml. SMILES: C[C@]12C(C[C@@H](OCCN(CC)CC)CC2)=CC[C@]3([H])[C@]1([H])CC[C@@]4(C)[C@@]3([H])CCC4=O.Cl. InChi Code: InChI=1S/C25H41NO2.ClH/c1-5-26(6-2)15-16-28-19-11-13-24(3)18(17-19)7-8-20-21-9-10-23(27)25(21,4)14-12-22(20)24,/h7,19-22H,5-6,8-17H2,1-4H3,1H/t19-,20-,21-,22-,24-,25-,/m0./s1. InChi Key: GZFYZYBWLCYBMI-MYZJJQSMSA-N.
Keywords: 3beta-[2-(diethylamino)ethoxy]-androst-5-en-17-one, monohydrochloride
Supplier: Cayman Chemical
Supplier-Nr: 10009085

Properties

Application: Cholesterol trafficking studies
MW: 424.1 D
Formula: C25H41NO2 . HCl
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 3039-71-2| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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