Tunicamycin 17:1 Mixture

Tunicamycin 17:1 is a mixture of tunicamycin structural isomers that contain a 17-carbon N-acyl chain with variable branching patterns. The N-acyl chain incorporated into tunicamycins, like tunicamycin 17:1, is derived from the same pool of cellular branched-chain fatty acids (BCFAs) in Streptomyces and directly impacts the biological activity of each individual tunicamycin variant. Purified tunicamycin 17:1 with iso or anteiso branching configurations inhibits bacterial phospho-MurNAc-pentapeptide transferase (MraY) with IC50 values of 0.12 and 0.9 µM, respectively.Synonyms: Tunicamycin D Mixture, Tunicamycin D2 Mixture, Tunicamycin X Mixture. Molecular Formula: C40H66N4O16. Formula Weight: 859.0. Purity: >95% (mixture of isomers). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 260 nm. SMILES: CC(N[C@H]1[C@@H](O[C@@]2([H])[C@H](NC(/C=C/CCCCCCCCCCCC(C)C)=O)[C@@H](O)[C@@H](O)[C@@H](C[C@@H](O)[C@@H]3[C@@H](O)[C@@H](O)[C@H](N4C=CC(NC4=O)=O)O3)O2)O[C@H](CO)[C@@H](O)[C@@H]1O)=O. InChi Code: InChI=1S/C40H66N4O16/c1-21(2)15-13-11-9-7-5-4-6-8-10-12-14-16-26(48)42-29-33(53)30(50)24(57-39(29)60-38-28(41-22(3)46)32(52)31(51)25(20-45)58-38)19-23(47)36-34(54)35(55)37(59-36)44-18-17-27(49)43-40(44)56/h14,16-18,21,23-25,28-39,45,47,50-55H,4-13,15,19-20H2,1-3H3,(H,41,46)(H,42,48)(H,43,49,56)/b16-14+/t23-,24-,25-,28-,29-,30+,31-,32-,33-,34+,35-,36-,37-,38-,39+/m1/s1. InChi Key: XCEPHNBEHQJSSB-LGJGITPNSA-N.