Trypacidin

Description: Trypacidin is a fungal metabolite originally isolated fromA. fumigatus.1It is active againstB. subtilisandM. bovis(MICs = 12.5 and 1.25 µg/ml, respectively), as well asT. cruziandT. gondii(MICs = 5-10 and 10-20 µg/ml, respectively).1,2It reduces viability and induces lysis of A549 human lung cancer cells (IC50s = 7.4 µM for both).3Trypacidin increases survival in a mouse model ofT. gondiiinfection when administered in six doses of 12.5 mg/kg each.1. Target: Others. Smiles: COC(=O)C1=CC(=O)C=C(OC)[C@@]11Oc2cc(C)cc(OC)c2C1=O. References: Balan, J., Ebringer, L., Nemec, P., et al.Antiprotozoal antibiotics. II. Isolation and characterization of trypacidin, a new antibiotic, active against Trypanosoma cruzi and Toxoplasma gondiiJ. Antibiot. (Tokyo)16157-160(1963)