Trypacidin

Trypacidin is a fungal metabolite originally isolated from A. fumigatus. It is active against B. subtilis and M. bovis (MICs = 12.5 and 1.25 µg/ml, respectively), as well as T. cruzi and T. gondii (MICs = 5-10 and 10-20 µg/ml, respectively). It reduces viability and induces lysis of A549 human lung cancer cells (IC50s = 7.4 µM for both). Trypacidin increases survival in a mouse model of T. gondii infection when administered in six doses of 12.5 mg/kg each.Formal Name: (-)-4,6'-dimethoxy-6-methyl-3,4'-dioxo-spiro[benzofuran-2(3H),1'-[2,5]cyclohexadiene]-2'-carboxylic acid, methyl ester. CAS Number: 1900-29-4. Molecular Formula: C18H16O7. Formula Weight: 344.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble. SMILES: O=C1C2(C(C(OC)=O)=CC(C=C2OC)=O)OC3=CC(C)=CC(OC)=C13. InChi Code: InChI=1S/C18H16O7/c1-9-5-12(22-2)15-13(6-9)25-18(16(15)20)11(17(21)24-4)7-10(19)8-14(18)23-3/h5-8H,1-4H3. InChi Key: KMZYINVXZDQCKC-UHFFFAOYSA-N. Origin: Fungus/Aspergillus sp..