TrkB Agonist Prodrug R13

A prodrug form of 7,8-dihydroxyflavone, increases hippocampal phosphorylated levels of TrkB, ERK, and Akt in 5XFAD mice at 43.6 mg/kg per day, p.o., decreases the number of malformed neurons and increases the number of neurons and active synapses in the hippocampus in 5XFAD mice, decreases the number of plaques and levels of Abeta40 in the hippocampus and frontal cortex and escape latency in the Morris water maze in 5XFAD mice, reduces the levels and activity of delta-secretase and the levels of Il-6, Tnf-alpha, and Il-1beta in brain homogenates from 5XFAD mice. Formulation: A solid. InChI: InChI=1S/C19H16N2O6/c1-20-18(23)26-14-9-8-12-13(22)10-15(11-6-4-3-5-7-11)25-16(12)17(14)27-19(24)21-2/h3-10H,1-2H3,(H,20,23)(H,21,24). InChIKey: NWWRHMSYZTWUBD-UHFFFAOYSA-N. SMILES: O=C(NC)OC1=C(OC(C2=CC=CC=C2)=CC3=O)C3=CC=C1OC(NC)=O