Trichlormethiazide

Trichlormethiazide is a thiazide diuretic. It inhibits sodium and chloride ion flux in the connecting tubule, but not the cortical collecting duct or the distal convoluted tubule, in isolated rabbit kidney tubules when used at a concentration of 1 mM. Trichlormethiazide increases relaxation induced by acetylcholine (Cay-23829) in norepinephrine-precontracted mesenteric arterial rings isolated from spontaneously hypertensive rats (EC50 = 33 nM). It increases urine output and urinary excretion of sodium, potassium, and chloride ions in dogs in a dose-dependent manner. It reduces systolic blood pressure in spontaneously hypertensive, but not normotensive, rats when administered at doses of 10 and 30 mg/kg. Formulations containing trichlormethiazide have been used in the treatment of edema and hypertension.Formal Name: 6-chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide, 1,1-dioxide. CAS Number: 133-67-5. Molecular Formula: C8H8Cl3N3O4S2. Formula Weight: 380.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5mg/mL, DMSO: 20mg/mL, DMSO:PBS (pH 7.2) (1:3): 0.25mg/mL. lambdamax: 225, 267, 313 nm. SMILES: NS(C1=C(Cl)C=C(NC(C(Cl)Cl)NS2(=O)=O)C2=C1)(=O)=O. InChi Code: InChI=1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16). InChi Key: LMJSLTNSBFUCMU-UHFFFAOYSA-N.