TRC051384

TRC051384 is an inducer of heat shock protein 70 (HSP70) expression. It increases HSP70 mRNA in HeLa cells and primary rat neurons when used at concentrations of 6.3 and 12.5 µM and activates the transcription factor heat shock factor 1 (Hsf1) in a reporter assay using HeLa cells at 25 µM. TRC051384 (1 µM) reduces apoptosis, decreases the levels of malondialdehyde (MDA), and prevents a decrease in the mitochondrial membrane potential induced by tert-butyl hydroperoxide in isolated human nucleus pulposus stem cells (NPSCs). Intraperitoneal administration of TRC051384 reduces penumbral incorporation into initial lesions, increases the percentage of animals surviving, and lowers neurological deficit scores in a rat model of cerebral ischemia.Formal Name: N-[2-(4-morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]-urea. CAS Number: 867164-40-7. Molecular Formula: C25H31N5O4. Formula Weight: 465.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 50 mg/ml. SMILES: O=C(NC1=CC=C(C(/C=C/C2=CC=CC(N3CCOCC3)=N2)=O)C=C1)NCCN4CCOCC4. InChi Code: InChI=1S/C25H31N5O4/c31-23(9-8-21-2-1-3-24(27-21)30-14-18-34-19-15-30)20-4-6-22(7-5-20)28-25(32)26-10-11-29-12-16-33-17-13-29/h1-9H,10-19H2,(H2,26,28,32)/b9-8+. InChi Key: SQTSPANZQDCPLB-CMDGGOBGSA-N.