Tranilast

Tranilast is an antiallergic agent. It inhibits prostaglandin E2 (PGE2, Cay-14010) and PGD2 (Cay-12010) production induced by A23187 (Cay-11016, Cay-22030) in isolated rat peritoneal mast cells when used at a concentration of 100 µM, as well as LPS-stimulated production of PGE2 and thromboxane B2 (TXB2, Cay-19030) in isolated human monocytes (IC50s = ~3 and ~35 µM, respectively). Tranilast (500 µM) reduces mast cell degranulation induced by compound 48/80 (Cay-22173). It inhibits VEGF-stimulated proliferation, migration, and tube formation of bovine retinal endothelial cells (IC50s = 22, 18, and 193 µM, respectively). Tranilast (200 mg/kg) prevents homologous passive cutaneous anaphylaxis (PCA) in guinea pigs. Formulations containing tranilast have been used in the treatment of asthma and keloid and hypertrophic scars.Formal Name: 2-[[3-(3,4-dimethoxyphenyl)-1-oxo-2-propen-1-yl]amino]-benzoic acid. CAS Number: 53902-12-8. Synonyms: 3,4-DAA, N-(3',4'-Dimethyoxycinnamoyl) Anthranilic Acid, N-5', MK 341, SB 252218. Molecular Formula: C18H17NO5. Formula Weight: 327.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 35 mg/ml, DMSO: 20 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): 0.2 mg/ml. lambdamax: 339 nm. SMILES: O=C(/C=C/C1=CC=C(OC)C(OC)=C1)NC2=C(C(O)=O)C=CC=C2. InChi Code: InChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+. InChi Key: NZHGWWWHIYHZNX-CSKARUKUSA-N.