TPX-0046

Item number	Size	Manual	SDS	Delivery time	Price
Cay41990-1	1 mg	-	-	5 - 10 business days*	139.00€
Cay41990-5	5 mg	-	-	5 - 10 business days*	620.00€
Cay41990-10	10 mg	-	-	5 - 10 business days*	1,101.00€
Cay41990-25	25 mg	-	-	5 - 10 business days*	2,406.00€

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A RET inhibitor (IC50 = 0.26 nM for the wild-type enzyme), selective for RET over a panel of 217... more

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Product information "TPX-0046"

A RET inhibitor (IC50 = 0.26 nM for the wild-type enzyme), selective for RET over a panel of 217 additional kinases but does inhibit 39 tyrosine kinases by > 50% at 26 nM, inhibits the phosphorylation of wild-type RET (IC50 = 21.9 nM) and 15 RET mutants (IC50s = 2.69-108 nM) in Ba/F3 cells. Formulation: A solid. InChI: InChI=1S/C21H21FN6O3/c1-11-6-23-20(29)14-8-25-28-10-17-19(26-18(14)28)27(15-3-2-4-16(15)31-17)9-12-5-13(22)7-24-21(12)30-11/h5,7-8,10-11,15-16H,2-4,6,9H2,1H3,(H,23,29)/t11-,15+,16-/m1/s1. InChIKey: BYYQDEOVMILBQT-XFBWCDHKSA-N. SMILES: O=C(C1=C2N=C3C(O[C@@](CCC4)([H])[C@@]4([H])N3CC(C=C(F)C=N5)=C5O6)=CN2N=C1)NC[C@H]6C

Keywords:	Enbezotinib, (3aS,11R,20aR)-7-fluoro-2,3,3a,12,13,20a-hexahydro-11-methyl-17,19-metheno-1H,5H-cyclopent[5,6][1,4]oxazino[3,4-i]pyrazolo[4,3-f]pyrido[3,2-l][1,4,8,10]oxatriazacyclotridecin-14(11H)-one
Supplier:	Cayman Chemical
Supplier-Nr:	41990

Properties

Application:	RET inhibitor
Immunogen:	424.4
MW:	424.4 D
Formula:	C21H21FN6O3
Purity:	>98%
Format:	Solid

Database Information

CAS :	2359650-19-2\| Matching products
KEGG ID :	K05126 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+20°C (International: -20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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