TPI-1

TPI-1 is an inhibitor of protein tyrosine phosphatases. TPI-1 (10 ng/ml) increases phosphorylated substrates of the phosphatase SHP-1 in Jurkat T cells, including pLck-pY394, pZap70, and pSlp76. It is selective for SHP-1 over SHP-2, having low activity at the SHP-2 substrate pERK1/2. It increases pLck-pY394 levels by approximately 3.3-fold and increases the number of IFN-gamma+ cells in mouse spleen ex vivo following a dose of approximately 3 mg/kg. Oral administration of TPI-1 (3 mg/kg per day) inhibits tumor growth in a B16 melanoma mouse xenograft model.Formal Name: 2-(2,5-dichlorophenyl)-2,5-cyclohexadiene-1,4-dione. CAS Number: 79756-69-7. Synonyms: Tyrosine Phosphatase Inhibitor 1. Molecular Formula: C12H6Cl2O2. Formula Weight: 253.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 1 mg/ml. lambdamax: 229 nm. SMILES: ClC1=C(C(C(C=C2)=O)=CC2=O)C=C(Cl)C=C1. InChi Code: InChI=1S/C12H6Cl2O2/c13-7-1-3-11(14)9(5-7)10-6-8(15)2-4-12(10)16/h1-6H. InChi Key: ZKHFYORNAYYOTM-UHFFFAOYSA-N.