Tofacitinib-d3 (citrate)

Tofacitinib-d3 (citrate)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay25046-1 1 mg -

6 - 10 business days*

915.00€
 
Tofacitinib-d3 (citrate) is intended for use as an internal standard for the quantification of... more
Product information "Tofacitinib-d3 (citrate)"
Tofacitinib-d3 (citrate) is intended for use as an internal standard for the quantification of tofacitinib (Cay-11598) by GC- or LC-MS. Tofacitinib is a potent, cell-permeable inhibitor of all JAK isoforms (IC50s = 6.1, 12, and 8 nM for JAK1, JAK2, and JAK3, respectively). It is selective for JAK1-3 over ROCK-2 and Lck (IC50s = 3,400 and 3,870 nM, respectively) as well as 28 additional kinases in enzyme assays (IC50s = >10,000 nM). It inhibits IL-2-mediated phosphorylation of JAK3 and STAT5 when used at a concentration of 30 ng/ml. Tofacitinib prevents rejection and prolongs survival in murine and cynomolgus monkey models of heterotopic heart and kidney transplantation, respectively. Formulations containing tofacitinib have been used in the prevention of organ allograft rejection as well as in the treatment of the inflammatory or autoimmune components of a host of diseases, including rheumatoid arthritis and ulcerative colitis.Formal Name: (3R,4R)-4-methyl-3-(methyl-d3-7H-pyrrolo[2,3-d]pyrimidin-4R-ylamino)-beta-oxo-1-piperidinepropanenitrile, 2-hydroxy-1,2,3-propanetricarboxylate. Synonyms: CP 690,550-d3. Molecular Formula: C16H17D3N6O . C6H8O7. Formula Weight: 507.5. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Water: soluble. SMILES: O=C(CC#N)N1CC[C@@H](C)[C@@H](N(C([2H])([2H])[2H])C2=NC=NC3=C2C=CN3)C1.OC(CC(O)=O)(C(O)=O)CC(O)=O. InChi Code: InChI=1S/C16H20N6O.C6H8O7/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16,7-3(8)1-6(13,5(11)12)2-4(9)10/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20),13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t11-,13+,/m1./s1/i2D3,. InChi Key: SYIKUFDOYJFGBQ-OGNQCBPOSA-N.
Keywords: Tofacitinib citrate-d3, 3-((3R,4R)-4-methyl-3-((methyl-d3)(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile 2-hydroxypropane-1,2,3-tricarboxylate
Supplier: Cayman Chemical
Supplier-Nr: 25046

Properties

Application: GC-/LC-MS internal standard, quantification
MW: 507.5 D
Formula: C16H17D3N6O . C6H8O7
Purity: >99% deuterated forms (d1-d3)
Format: Solid

Database Information

KEGG ID : K04447 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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